Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen TH
PROVIDER: S-EPMC6278278 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nguyen Thanh Hung TH Barr Frederic G FG
Molecules (Basel, Switzerland) 20181028 11
Rhabdomyosarcoma (RMS) is a family of soft tissue cancers that are related to the skeletal muscle lineage and predominantly occur in children and young adults. A specific chromosomal translocation t(2;13)(q35;q14) that gives rise to the chimeric oncogenic transcription factor PAX3-FOXO1 has been identified as a hallmark of the aggressive alveolar subtype of RMS. PAX3-FOXO1 cooperates with additional molecular changes to promote oncogenic transformation and tumorigenesis in various human and muri ...[more]