Ontology highlight
ABSTRACT:
SUBMITTER: Tashiro Y
PROVIDER: S-EPMC6278453 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Tashiro Yuusuke Y Sakai Ryo R Hirose-Sugiura Tomoko T Kato Yukio Y Matsuo Hirotaka H Takada Tappei T Suzuki Hiroshi H Makino Toshiaki T
Molecules (Basel, Switzerland) 20181101 11
(1) Background: Crude drugs used in traditional Japanese Kampo medicine or folk medicine are major sources of new chemical entities for drug discovery. We screened the inhibitory potential of these crude drugs against urate transporter 1 (URAT1) to discover new drugs for hyperuricemia. (2) Methods: We prepared the MeOH extracts of 107 different crude drugs, and screened their inhibitory effects on URAT1 by measuring the uptake of uric acid by HEK293/PDZK1 cells transiently transfected with URAT1 ...[more]