Ontology highlight
ABSTRACT:
SUBMITTER: Ejjoummany A
PROVIDER: S-EPMC6278517 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20181023 11
The design of some novel di-(het)arylated-3<i>H</i>-pyrido[1',2':1,5]pyrazolo[4,3-<i>d</i>]pyrimidine derivatives is reported. The series was developed from 1-aminopyridinium iodide, which afforded the key intermediate bearing two thiomethyl and amide functions, each of them useful for palladium catalyzed cross coupling reactions by alkyl sulfur release and C-O activation, respectively. The two regioselective and successive cross-coupling reactions were first carried out in C-4 by in situ C-O ac ...[more]