Ontology highlight
ABSTRACT:
SUBMITTER: Dong ST
PROVIDER: S-EPMC6278556 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Dong Song-Tao ST Li Ying Y Yang Hao-Tian HT Wu Yin Y Li Ya-Jing YJ Ding Cong-Yang CY Meng Lu L Dong Zhan-Jun ZJ Zhang Yuan Y
Molecules (Basel, Switzerland) 20181106 11
Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors. In this research, an original analysis method was established for the quantification of osimertinib by ultra-performance liquid chromatography with time of flight mass spectrometry (UPLC-TOF-MS) in rat plasma. After protein precipitation with acetonitrile and sorafinib (internal standard, IS), they were chromatographed through a Waters XTerr ...[more]