Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC6278818 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Wang Weicang W Yang Jun J Nimiya Yoshiki Y Lee Kin Sing Stephen KSS Sanidad Katherine K Qi Weipeng W Sukamtoh Elvira E Park Yeonhwa Y Liu Zhenhua Z Zhang Guodong G
The Journal of nutritional biochemistry 20170621
Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer; however, the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the role of eicosanoid signaling in the anti-colorectal cancer effects of ω-3 PUFAs. Our results showed that dietary feeding of ω-3 PUFAs-rich diets suppressed growth of MC38 colorectal tumor, and modulated profiles of fatty acids and eicosanoid metabolites in ...[more]