Ontology highlight
ABSTRACT:
SUBMITTER: Simmons JD
PROVIDER: S-EPMC6278832 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature reviews. Immunology 20180901 9
Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a long-lived latent infection in a substantial proportion of the human population. Multiple lines of evidence suggest that some individuals are resistant to latent M. tuberculosis infection despite long-term and intense exposure, and we term these individuals 'resisters'. In this Review, we discuss the epidemiological and genetic data that support the existence of resisters and propose criteria to optimally defi ...[more]