Ontology highlight
ABSTRACT:
SUBMITTER: Choueiri TK
PROVIDER: S-EPMC6279111 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Choueiri T K TK Pal S K SK McDermott D F DF Morrissey S S Ferguson K C KC Holland J J Kaelin W G WG Dutcher J P JP
Annals of oncology : official journal of the European Society for Medical Oncology 20140514 8
<h4>Background</h4>Cabozantinib targets tyrosine kinases including the hepatocyte growth factor receptor (MET) and vascular endothelial growth factor (VEGF) receptor 2, which are important drug targets in renal cell carcinoma (RCC).<h4>Patients and methods</h4>This single-arm open-label phase I trial evaluated the safety and tolerability of cabozantinib in heavily pretreated patients with metastatic clear cell RCC.<h4>Results</h4>The study enrolled 25 RCC patients for whom standard therapy had f ...[more]