Ontology highlight
ABSTRACT:
SUBMITTER: Collins JC
PROVIDER: S-EPMC6279377 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Collins Jason C JC Ghalei Homa H Doherty Joanne R JR Huang Haina H Culver Rebecca N RN Karbstein Katrin K
The Journal of cell biology 20181022 12
The correct assembly of ribosomes from ribosomal RNAs (rRNAs) and ribosomal proteins (RPs) is critical, as indicated by the diseases caused by RP haploinsufficiency and loss of RP stoichiometry in cancer cells. Nevertheless, how assembly of each RP is ensured remains poorly understood. We use yeast genetics, biochemistry, and structure probing to show that the assembly factor Ltv1 facilitates the incorporation of Rps3, Rps10, and Asc1/RACK1 into the small ribosomal subunit head. Ribosomes from L ...[more]