Ontology highlight
ABSTRACT:
SUBMITTER: Shima T
PROVIDER: S-EPMC6279379 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
The Journal of cell biology 20181008 12
Kinesin-1, the founding member of the kinesin superfamily of proteins, is known to use only a subset of microtubules for transport in living cells. This biased use of microtubules is proposed as the guidance cue for polarized transport in neurons, but the underlying mechanisms are still poorly understood. Here, we report that kinesin-1 binding changes the microtubule lattice and promotes further kinesin-1 binding. This high-affinity state requires the binding of kinesin-1 in the nucleotide-free ...[more]