Ontology highlight
ABSTRACT:
SUBMITTER: Xiao R
PROVIDER: S-EPMC6279528 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Xiao Run R Bergin Stephen M SM Huang Wei W Mansour Anthony G AG Liu Xianglan X Judd Ryan T RT Widstrom Kyle J KJ Queen Nicholas J NJ Wilkins Ryan K RK Siu Jason J JJ Ali Seemaab S Caligiuri Michael A MA Cao Lei L
Brain, behavior, and immunity 20181001
Environmental and social factors have profound impacts on immune homeostasis. Our work on environmental enrichment (EE) has revealed a novel anti-obesity and anticancer phenotype associated with enhanced activity of CD8<sup>+</sup> cytotoxic T lymphocytes in secondary lymphoid tissues. Here we investigated how an EE modulated thymus and thymocyte development. EE decreased thymus mass and cellularity, decreased the double positive thymocyte population, increased the proportion of CD8<sup>+</sup> ...[more]