Ontology highlight
ABSTRACT:
SUBMITTER: Hale LJ
PROVIDER: S-EPMC6279764 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Hale Lorna J LJ Howden Sara E SE Phipson Belinda B Lonsdale Andrew A Er Pei X PX Ghobrial Irene I Hosawi Salman S Wilson Sean S Lawlor Kynan T KT Khan Shahnaz S Oshlack Alicia A Quinlan Catherine C Lennon Rachel R Little Melissa H MH
Nature communications 20181204 1
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria. Studies into human podocytopathies to date have employed primary or immortalised podocyte cell lines cultured in 2D. Here we compare 3D human glomeruli sieved from induced pluripotent stem cell-derived kidney organoids with conditionally immortalised human podocyte cell lines, revealing improved po ...[more]