Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Marked mitral prosthesis rocking motion preceding atrioventricular groove rupture.

ABSTRACT: Rupture of the atrioventricular groove is an uncommon but dreaded complication of mitral valve replacement. We present the case of a 74-year-old male submitted to mitral valve surgery, complicated by atrioventricular groove rupture presaged by the excessive rocking movement of the prosthesis seen in the pre-discharge transthoracic echocardiogram. .

SUBMITTER: Sousa AIC

PROVIDER: S-EPMC6280011 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Marked mitral prosthesis rocking motion preceding atrioventricular groove rupture.

Sousa Alexandra Isabel Coelho AIC Gonçalves Alexandra Maria Gomes Silva AMGS Madureira António José Barbosa Silva AJBS Almeida Jorge Manuel Santos JMS Torres José Manuel Lima Pinheiro JMLP

Journal of cardiology cases 20141018 1

Rupture of the atrioventricular groove is an uncommon but dreaded complication of mitral valve replacement. We present the case of a 74-year-old male submitted to mitral valve surgery, complicated by atrioventricular groove rupture presaged by the excessive rocking movement of the prosthesis seen in the pre-discharge transthoracic echocardiogram. <<b>Learning objective:</b> Valvular prosthesis rocking movement has been typically associated with paravalvular leaks and fistulae. To the best of our ...[more]

PMID: 30546529

Similar Datasets

Late atrioventricular groove disruption presenting 7 years after mitral valve replacement: a case report.

Project description:Background:Left ventricular rupture is the most feared complication in mitral valve surgery. Despite its low incidence, mortality rates can reach up to 75%. It usually presents on the operating room with a dissecting haematoma followed by massive bleeding after discontinuing cardiopulmomary bypass. However, cardiac rupture may be contained by adherent pericardium or scar tissue leading to chronic formation of a pseudoaneurysm (PSA). Case summary:A 44-year-old man came to our institution with acute heart failure triggered by community-acquired pneumonia. He underwent mitral valve replacement with a mechanical prosthesis 7?years before and reported suffering from chronic worsening dyspnoea for 18?months. He underwent chest computed tomography scan and cardiac magnetic resonance imaging (CMRI), which showed two extensive left ventricular (LV) multilobulated PSAs. An operative approach was chosen and a tear was found on the posterior atrioventricular groove (AVG), communicating left ventricle with the PSA, which was closed with bovine pericardium patch. After weaning from cardiopulmonary bypass, he presented a diffuse life-threatening bleeding. The surgeons packed his chest with compresses before closing the sternum and he was operatively revised after 48?h. Post-operative CMRI showed that one of the PSAs remained connected with the LV. Despite of all, 1 year after hospital discharge, he remains asymptomatic without signs of heart failure. Discussion:This case illustrates PSAs' potential to grow for a long period before causing symptoms, the complexity and risks of chronic AVG disruption surgery and the importance of careful annular manipulation and debridement as preventive measures in mitral valve surgery.

| S-EPMC7319809 | biostudies-literature

Slow conformational exchange and overall rocking motion in ubiquitin protein crystals.

Project description:Proteins perform their functions in solution but their structures are most frequently studied inside crystals. Here we probe how the crystal packing alters microsecond dynamics, using solid-state NMR measurements and multi-microsecond MD simulations of different crystal forms of ubiquitin. In particular, near-rotary-resonance relaxation dispersion (NERRD) experiments probe angular backbone motion, while Bloch-McConnell relaxation dispersion data report on fluctuations of the local electronic environment. These experiments and simulations reveal that the packing of the protein can significantly alter the thermodynamics and kinetics of local conformational exchange. Moreover, we report small-amplitude reorientational motion of protein molecules in the crystal lattice with an ~3-5° amplitude on a tens-of-microseconds time scale in one of the crystals, but not in others. An intriguing possibility arises that overall motion is to some extent coupled to local dynamics. Our study highlights the importance of considering the packing when analyzing dynamics of crystalline proteins.X-ray crystallography is the main method for protein structure determination. Here the authors combine solid-state NMR measurements and molecular dynamics simulations and show that crystal packing alters the thermodynamics and kinetics of local conformational exchange as well as overall rocking motion of protein molecules in the crystal lattice.

| S-EPMC5529581 | biostudies-literature

Observing the overall rocking motion of a protein in a crystal.

Project description:The large majority of three-dimensional structures of biological macromolecules have been determined by X-ray diffraction of crystalline samples. High-resolution structure determination crucially depends on the homogeneity of the protein crystal. Overall 'rocking' motion of molecules in the crystal is expected to influence diffraction quality, and such motion may therefore affect the process of solving crystal structures. Yet, so far overall molecular motion has not directly been observed in protein crystals, and the timescale of such dynamics remains unclear. Here we use solid-state NMR, X-ray diffraction methods and μs-long molecular dynamics simulations to directly characterize the rigid-body motion of a protein in different crystal forms. For ubiquitin crystals investigated in this study we determine the range of possible correlation times of rocking motion, 0.1-100 μs. The amplitude of rocking varies from one crystal form to another and is correlated with the resolution obtainable in X-ray diffraction experiments.

| S-EPMC4600728 | biostudies-literature

Balloon-expandable prosthesis for open mitral replacement with a calcified mitral annulus.

Project description: Not available

| S-EPMC8299984 | biostudies-literature

Robotic mitral replacement for a degenerated valve-in-valve transcatheter mitral prosthesis

Project description: Not available

| S-EPMC10579781 | biostudies-literature

Periannular Mitral Valve Prosthesis Crypts Mimicking Periprosthetic Abscesses.

Project description:Mitral annular abscesses are rare and can be caused by infective endocarditis. We present the case of a patient with an infected mitral prosthesis, with multiple suspected periprosthetic abscesses. However, perioperative inspection showed a supra-annular implanted prosthesis.

| S-EPMC11328772 | biostudies-literature

Fracture of an Edwards Duromedics Mitral Prosthesis Leaflet.

Project description:We report the case of a 54-year-old patient who underwent a repeated mitral replacement after a nontraumatic fracture of a leaflet of an Edwards Duromedics (Baxter) mechanical prosthesis that was performed 33 years after implantation. This paper discusses the different options for surgical management of such a complication. (Level of Difficulty: Intermediate.).

| S-EPMC8299850 | biostudies-literature

Caged-Ball Mitral Prosthesis Explanted After 50 Years.

Project description:We report a unique case of a Starr-Edwards prosthesis (model 6310, cloth covered) implanted in the mitral position by Christian Barnard that was successfully explanted and replaced after 50 years, the longest period free from valve dysfunction ever reported. Reoperation also included replacement of the native aortic valve combined with tricuspid valve annuloplasty. (Level of Difficulty: Beginner.).

| S-EPMC8311380 | biostudies-literature

Hybrid mics mitral valve replacement with TAVR prosthesis in incomplete circumferential mitral annulus calcification.

Project description: Not available

| S-EPMC10439705 | biostudies-literature

Robotic mitral valve repair for papillary muscle rupture.

Project description: Not available

| S-EPMC9579726 | biostudies-literature