MiRTrace reveals the organismal origins of microRNA sequencing data.
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ABSTRACT:
SUBMITTER: Kang W
PROVIDER: S-EPMC6280396 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
miRTrace reveals the organismal origins of microRNA sequencing data.
Kang Wenjing W Eldfjell Yrin Y Fromm Bastian B Estivill Xavier X Biryukova Inna I Friedländer Marc R MR
Genome biology 20181204 1
We present here miRTrace, the first algorithm to trace microRNA sequencing data back to their taxonomic origins. This is a challenge with profound implications for forensics, parasitology, food control, and research settings where cross-contamination can compromise results. miRTrace accurately (> 99%) assigns real and simulated data to 14 important animal and plant groups, sensitively detects parasitic infection in mammals, and discovers the primate origin of single cells. Applying our algorithm ...[more]
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