Dataset Information

Prognostic significance of sealed-off perforation in colon cancer: a prospective cohort study.

ABSTRACT:

Background

Perforated colon cancer is a rare complication, but has a high risk of recurrence. However, most studies have not distinguished sealed-off perforation from free perforation, and the prognosis is unclear. The aim of this study was to evaluate the oncologic outcome of colon cancer with sealed-off perforation.

Methods

Eighty-six consecutive patients who underwent resection for colon cancer with sealed-off or free perforation were included. We defined sealed-off perforation as a colon perforation with localized abscess identified on operative, computed tomography, or pathologic findings, with no evidence of free perforation, including fecal contamination and dirty fluid collection in the peritoneal cavity. Oncologic outcomes were compared between patients with colon cancer with sealed-off perforation and free perforation using a log-rank test and Cox regression analysis.

Results

The sealed-off perforation group included 62 patients, and 24 patients were in the free perforation group. TNM stage and lymphatic, venous, and perineural invasion were similar between the groups. The median follow-up period was 28.9?months (range 0-159). The sealed-off perforation group had better prognosis compared with the free perforation group in terms of progression-free survival (PFS) and overall survival (OS), although there were no statistically significant differences in PFS (5-year PFS 53.7% vs. 40.5%, p?=?0.148; 5-year OS 53.6% vs. 22.9%, p?=?0.001). However, in multivariable analysis using the Cox progression test, sealed-off perforation did not show a significant effect on cancer progression (p =?0.138) and OS (p =?0.727).

Conclusions

Colon cancer with sealed-off perforation showed no difference in prognosis compared with free perforation.

SUBMITTER: Lee KY

PROVIDER: S-EPMC6280413 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Publications

Prognostic significance of sealed-off perforation in colon cancer: a prospective cohort study.

Lee Kil-Yong KY Park Ji Won JW Song Inho I Lee Ki-Young KY Cho Sangsik S Kwon Yoon-Hye YH Kim Min Jung MJ Ryoo Seung-Bum SB Jeong Seung-Yong SY Park Kyu Joo KJ

World journal of surgical oncology 20181204 1

<h4>Background</h4>Perforated colon cancer is a rare complication, but has a high risk of recurrence. However, most studies have not distinguished sealed-off perforation from free perforation, and the prognosis is unclear. The aim of this study was to evaluate the oncologic outcome of colon cancer with sealed-off perforation.<h4>Methods</h4>Eighty-six consecutive patients who underwent resection for colon cancer with sealed-off or free perforation were included. We defined sealed-off perforation ...[more]

PMID: 30514318

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Dataset Information

Prognostic significance of sealed-off perforation in colon cancer: a prospective cohort study.

Background

Methods

Results

Conclusions

Publications

Prognostic significance of sealed-off perforation in colon cancer: a prospective cohort study.

Similar Datasets

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