Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.
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ABSTRACT:
SUBMITTER: Chen YM
PROVIDER: S-EPMC6280483 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy.
Chen Yi-Ming YM Chang Chun-Yu CY Chen Hsin-Hua HH Hsieh Chia-Wei CW Tang Kuo-Tung KT Yang Meng-Chun MC Lan Joung-Liang JL Chen Der-Yuan DY
Arthritis research & therapy 20181205 1
<h4>Background</h4>Increasing evidence indicates a pathogenic role of deregulated autophagy in rheumatoid arthritis (RA). We examined the relationship between autophagy and inflammatory parameters in patients with RA receiving biologic therapy.<h4>Methods</h4>In 72 patients with RA and 20 healthy control subjects (HC), autophagosome levels were determined by the mean fluorescence intensity (MFI) of autophagosomotropic dye incorporated into circulating immune cells, and p62 expression levels in i ...[more]
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