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New Opportunities for Targeting the Androgen Receptor in Prostate Cancer.

ABSTRACT: Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

SUBMITTER: Centenera MM

PROVIDER: S-EPMC6280715 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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New Opportunities for Targeting the Androgen Receptor in Prostate Cancer.

Centenera Margaret M MM Selth Luke A LA Ebrahimie Esmaeil E Butler Lisa M LM Tilley Wayne D WD

Cold Spring Harbor perspectives in medicine 20181203 12

Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for ...[more]

PMID: 29530945

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