Dataset Information

Automatic calculation of myocardial external efficiency using a single ¹¹C-acetate PET scan.

ABSTRACT:

Background

Myocardial external efficiency (MEE) is defined as the ratio of kinetic energy associated with cardiac work [forward cardiac output (FCO)*mean systemic pressure] and the chemical energy from oxygen consumed (MVO₂) by the left ventricular mass (LVM). We developed a fully automated method for estimating MEE based on a single ¹¹C-acetate PET scan without ECG-gating.

Methods and results

Ten healthy controls, 34 patients with aortic valve stenosis (AVS), and 20 patients with mitral valve regurgitation (MVR) were recruited in a dual-center study. MVO₂ was calculated using washout of ¹¹C -acetate activity. FCO and LVM were calculated automatically using dynamic PET and parametric image formation. FCO and LVM were also obtained using cardiac magnetic resonance (CMR) in all subjects. The correlation between MEE_PET-CMR and MEE_PET was high (r = 0.85, P < 0.001) without significant bias. MEE_PET was 23.6 ± 4.2% for controls and was lowered in AVS (17.2 ± 4.3%, P < 0.001) and in MVR (18.0 ± 5.2%, P = 0.004). MEE_PET was strongly associated with both NYHA class (P < 0.001) and the magnitude of valvular dysfunction (mean aortic gradient: P < 0.001, regurgitant fraction: P = 0.009).

Conclusion

A single ¹¹C-acetate PET yields accurate and automated MEE results on different scanners. MEE might provide an unbiased measurement of the phenotypic response to valvular disease.

SUBMITTER: Harms HJ

PROVIDER: S-EPMC6280778 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Publications

Automatic calculation of myocardial external efficiency using a single <sup>11</sup>C-acetate PET scan.

Harms Hendrik J HJ Hansson Nils Henrik S NHS Kero Tanja T Baron Tomasz T Tolbod Lars P LP Kim Won Y WY Frøkiær Jørgen J Flachskampf Frank A FA Wiggers Henrik H Sörensen Jens J

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20180626 6

<h4>Background</h4>Myocardial external efficiency (MEE) is defined as the ratio of kinetic energy associated with cardiac work [forward cardiac output (FCO)*mean systemic pressure] and the chemical energy from oxygen consumed (MVO<sub>2</sub>) by the left ventricular mass (LVM). We developed a fully automated method for estimating MEE based on a single <sup>11</sup>C-acetate PET scan without ECG-gating.<h4>Methods and results</h4>Ten healthy controls, 34 patients with aortic valve stenosis (AVS) ...[more]

PMID: 29946824

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Dataset Information

Automatic calculation of myocardial external efficiency using a single ¹¹C-acetate PET scan.

Background

Methods and results

Conclusion

Publications

Automatic calculation of myocardial external efficiency using a single <sup>11</sup>C-acetate PET scan.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Automatic calculation of myocardial external efficiency using a single 11C-acetate PET scan.

Background

Methods and results

Conclusion

Publications

Automatic calculation of myocardial external efficiency using a single <sup>11</sup>C-acetate PET scan.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Automatic calculation of myocardial external efficiency using a single ¹¹C-acetate PET scan.