Ontology highlight
ABSTRACT:
SUBMITTER: Jones CL
PROVIDER: S-EPMC6280965 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Jones Courtney L CL Stevens Brett M BM D'Alessandro Angelo A Reisz Julie A JA Culp-Hill Rachel R Nemkov Travis T Pei Shanshan S Khan Nabilah N Adane Biniam B Ye Haobin H Krug Anna A Reinhold Dominik D Smith Clayton C DeGregori James J Pollyea Daniel A DA Jordan Craig T CT
Cancer cell 20181101 5
In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino acid uptake, steady-state levels, and catabolism are all elevated in the leukemia stem cell (LSC) population. Furthermore, LSCs isolated from de novo AML patients are uniquely reliant on amino acid metabolism for oxidative phosphorylation and survival. Pharmacological inhibition of amino acid metabolism reduces oxida ...[more]