Recent advances in understanding inhibitor of apoptosis proteins.
Ontology highlight
ABSTRACT:
SUBMITTER: Lalaoui N
PROVIDER: S-EPMC6281012 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Recent advances in understanding inhibitor of apoptosis proteins.
Lalaoui Najoua N Vaux David Lawrence DL
F1000Research 20181203
The inhibitor of apoptosis proteins (IAPs) are a family of proteins that were chiefly known for their ability to inhibit apoptosis by blocking caspase activation or activity. Recent research has shown that cellular IAP1 (cIAP1), cIAP2, and X-linked IAP (XIAP) also regulate signaling by receptors of the innate immune system by ubiquitylating their substrates. These IAPs thereby act at the intersection of pathways leading to cell death and inflammation. Mutation of IAP genes can impair tissue home ...[more]
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