TrpV1 receptor activation rescues neuronal function and network gamma oscillations from A?-induced impairment in mouse hippocampus in vitro.

ABSTRACT: Amyloid-? peptide (A?) forms plaques in Alzheimer's disease (AD) and is responsible for early cognitive deficits in AD patients. Advancing cognitive decline is accompanied by progressive impairment of cognition-relevant EEG patterns such as gamma oscillations. The endocannabinoid anandamide, a TrpV1-receptor agonist, reverses hippocampal damage and memory impairment in rodents and protects neurons from A?-induced cytotoxic effects. Here, we investigate a restorative role of TrpV1-receptor activation against A?-induced degradation of hippocampal neuron function and gamma oscillations. We found that the TrpV1-receptor agonist capsaicin rescues A?-induced degradation of hippocampal gamma oscillations by reversing both the desynchronization of AP firing in CA3 pyramidal cells and the shift in excitatory/inhibitory current balance. This rescue effect is TrpV1-receptor-dependent since it was absent in TrpV1 knockout mice or in the presence of the TrpV1-receptor antagonist capsazepine. Our findings provide novel insight into the network mechanisms underlying cognitive decline in AD and suggest TrpV1 activation as a novel therapeutic target.

SUBMITTER: Balleza-Tapia H 

PROVIDER: S-EPMC6281315 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature