Ontology highlight
ABSTRACT:
SUBMITTER: Vanassche T
PROVIDER: S-EPMC6281407 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Vanassche Thomas T Peetermans Marijke M Van Aelst Lucas N L LN Peetermans Willy E WE Verhaegen Jan J Missiakas Dominique M DM Schneewind Olaf O Hoylaerts Marc F MF Verhamme Peter P
The Journal of infectious diseases 20130326 1
Staphylococcus aureus (S. aureus) is a frequent cause of catheter-related infections. S. aureus secretes the coagulases staphylocoagulase and von Willebrand factor-binding protein, both of which form a staphylothrombin complex upon binding to prothrombin. Although fibrinogen and fibrin facilitate the adhesion of S. aureus to catheters, the contribution of staphylothrombin-mediated fibrin has not been examined. In this study, we use a S. aureus mutant lacking both coagulases (Δcoa/vwb) and dabiga ...[more]