Ontology highlight
ABSTRACT:
SUBMITTER: Hafner-Bratkovic I
PROVIDER: S-EPMC6281599 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Hafner-Bratkovič Iva I Sušjan Petra P Lainšček Duško D Tapia-Abellán Ana A Cerović Kosta K Kadunc Lucija L Angosto-Bazarra Diego D Pelegrin Pablo P Jerala Roman R
Nature communications 20181205 1
NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger signals and regulation of activation. Here we show by reconstitution of truncated and chimeric variants into Nlrp3<sup>-/-</sup> macrophages that the leucine-rich repeat domain is dis ...[more]