Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities.
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ABSTRACT:
SUBMITTER: Fadason T
PROVIDER: S-EPMC6281603 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities.
Fadason Tayaza T Schierding William W Lumley Thomas T O'Sullivan Justin M JM
Nature communications 20181205 1
Clinical studies of non-communicable diseases identify multimorbidities that suggest a common set of predisposing factors. Despite the fact that humans have ~24,000 genes, we do not understand the genetic pathways that contribute to the development of multimorbid non-communicable disease. Here we create a multimorbidity atlas of traits based on pleiotropy of spatially regulated genes. Using chromatin interaction and expression Quantitative Trait Loci (eQTL) data, we analyse 20,782 variants (p < ...[more]
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