Ontology highlight
ABSTRACT:
SUBMITTER: Husson T
PROVIDER: S-EPMC6281607 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Translational psychiatry 20181205 1
This study aims at assessing the burden of rare (minor allele frequency < 1%) predicted damaging variants in the whole exome of 92 bipolar I disorder (BD) patients and 1051 controls of French ancestry. Patients exhibiting an extreme phenotype (earlier onset and family history of mood disorder) were preferentially included to increase the power to detect an association. A collapsing strategy was used to test the overall burden of rare variants in cases versus controls at the gene level. Only prot ...[more]