Ontology highlight
ABSTRACT:
SUBMITTER: Husson T
PROVIDER: S-EPMC6281607 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Husson Thomas T Duboc Jean-Baptiste JB Quenez Olivier O Charbonnier Camille C Rotharmel Maud M Cuenca Macarena M Jegouzo Xavier X Richard Anne-Claire AC Frebourg Thierry T Deleuze Jean-François JF Boland Anne A Genin Emmanuelle E Debette Stéphanie S Tzourio Christophe C Campion Dominique D Nicolas Gaël G Guillin Olivier O
Translational psychiatry 20181205 1
This study aims at assessing the burden of rare (minor allele frequency < 1%) predicted damaging variants in the whole exome of 92 bipolar I disorder (BD) patients and 1051 controls of French ancestry. Patients exhibiting an extreme phenotype (earlier onset and family history of mood disorder) were preferentially included to increase the power to detect an association. A collapsing strategy was used to test the overall burden of rare variants in cases versus controls at the gene level. Only prot ...[more]