Ontology highlight
ABSTRACT:
SUBMITTER: Liang B
PROVIDER: S-EPMC6281613 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Liang Bo B Li Hong H He Quanze Q Li Haibo H Kong Lingyin L Xuan Liming L Xia Yingying Y Shen Jingjing J Mao Yan Y Li Yixue Y Wang Ting T Zhao Yi-Lei YL
Scientific reports 20181205 1
Measurement of cell-free fetal DNA (cffDNA) is an indispensable process for non-invasive prenatal screening (NIPS). According to recent studies, cffDNA in maternal plasma can be enriched for various lengths of fragments, and a sufficient amount of cffDNA can effectively eliminate background interference on the part of maternal DNA. Therefore, we developed a simple and effective separation method, improved NIPS (iNIPS), that enriches the fetal fraction and improves the accuracy of NIPS for fetal ...[more]