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Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones.

ABSTRACT: Deacetylation is the removal of an acetyl group and occurs on a plethora of targets and for a wide range of biological reasons. Several pathogens deacetylate their surface carbohydrates to evade immune response or to support biofilm formation. Furthermore, dynamic acetylation/deacetylation cycles govern processes from chromatin remodeling to posttranslational modifications that compete with phosphorylation. Acetylation usually occurs on nitrogen and oxygen atoms and are referred to as N- and O-acetylation, respectively. This review discusses the structural prerequisites that enzymes must have to catalyze the deacetylation reaction, and how they adapted by formation of specific substrate and metal binding sites.

SUBMITTER: Burger M

PROVIDER: S-EPMC6281622 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones.

Bürger Marco M Chory Joanne J

Communications biology 20181205

Deacetylation is the removal of an acetyl group and occurs on a plethora of targets and for a wide range of biological reasons. Several pathogens deacetylate their surface carbohydrates to evade immune response or to support biofilm formation. Furthermore, dynamic acetylation/deacetylation cycles govern processes from chromatin remodeling to posttranslational modifications that compete with phosphorylation. Acetylation usually occurs on nitrogen and oxygen atoms and are referred to as N- and O-a ...[more]

PMID: 30534609

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Erratum: Publisher Correction: Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones.

Project description:[This corrects the article DOI: 10.1038/s42003-018-0214-4.].

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