Ontology highlight
ABSTRACT:
SUBMITTER: Choi E
PROVIDER: S-EPMC6281718 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in cell and developmental biology 20181129
The spindle checkpoint ensures accurate chromosome segregation during mitosis and guards against aneuploidy. Insulin signaling governs metabolic homeostasis and cell growth, and its dysregulation leads to metabolic disorders, such as diabetes. These critical pathways have been extensively investigated, but a link between the two has not been established until recently. Our recent study reveals a critical role of spindle checkpoint regulators in insulin signaling and metabolic homeostasis through ...[more]