Ontology highlight
ABSTRACT:
SUBMITTER: Degen M
PROVIDER: S-EPMC6281767 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Degen Martin M Wiederkehr Astrid A La Scala Giorgio C GC Carmann Christina C Schnyder Isabelle I Katsaros Christos C
Frontiers in physiology 20181129
To gain more understanding of the complex molecular processes underlying cleft lip/palate (CLP), we established a unique human cell bank, consisting of keratinocytes and corresponding fibroblasts from individual CLP patients as a new study tool. After their careful characterization, we used such patient-derived cell cultures as well as control keratinocytes for <i>in vitro</i> differentiation and proliferation assays. Foreskin-derived control cells as a group showed significant higher induction ...[more]