Ontology highlight
ABSTRACT:
SUBMITTER: Zaidan N
PROVIDER: S-EPMC6282070 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Zaidan Nada N Ottersbach Katrin K
Open biology 20181121 11
The transcription factor Gata3 is crucial for the development of several tissues and cell lineages both during development as well as postnatally. This importance is apparent from the early embryonic lethality following germline Gata3 deletion, with embryos displaying a number of phenotypes, and from the fact that Gata3 has been implicated in several cancer types. It often acts at the level of stem and progenitor cells in which it controls the expression of key lineage-determining factors as wel ...[more]