Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity.
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ABSTRACT:
SUBMITTER: Tal T
PROVIDER: S-EPMC6282194 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity.
Tal Tamara T Kilty Claire C Smith Andrew A LaLone Carlie C Kennedy Brendán B Tennant Alan A McCollum Catherine W CW Bondesson Maria M Knudsen Thomas T Padilla Stephanie S Kleinstreuer Nicole N
Reproductive toxicology (Elmsford, N.Y.) 20161219
Chemically-induced vascular toxicity during embryonic development may cause a wide range of adverse effects. To identify putative vascular disrupting chemicals (pVDCs), a predictive pVDC signature was constructed from 124 U.S. EPA ToxCast high-throughput screening (HTS) assays and used to rank 1060 chemicals for their potential to disrupt vascular development. Thirty-seven compounds were selected for targeted testing in transgenic Tg(kdrl:EGFP) and Tg(fli1:EGFP) zebrafish embryos to identify che ...[more]
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