Ontology highlight
ABSTRACT:
SUBMITTER: Tenda K
PROVIDER: S-EPMC6282528 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Tenda Keisuke K van Gerven Benice B Arts Remco R Hiruta Yuki Y Merkx Maarten M Citterio Daniel D
Angewandte Chemie (International ed. in English) 20180919 47
This work reports on fully integrated "sample-in-signal-out" microfluidic paper-based analytical devices (μPADs) relying on bioluminescence resonance energy transfer (BRET) switches for analyte recognition and colorimetric signal generation. The devices use BRET-based antibody sensing proteins integrated into vertically assembled layers of functionalized paper, and their design enables sample volume-independent and fully reagent-free operation, including on-device blood plasma separation. User o ...[more]