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Mid-Luteal 17-OH Progesterone Levels in 614 Women Undergoing IVF-Treatment and Fresh Embryo Transfer-Daytime Variation and Impact on Live Birth Rates.


ABSTRACT: Introduction: Corpus luteum (CL) produces progesterone (P4) and 17-OH progesterone (17-OH P4) during the luteal phase. Contrary to P4, 17-OH P4 is not supplied as part of the luteal phase support following IVF-treatment. Therefore, measuring endogenous serum 17-OH P4 levels may more accurately reflect the CL function compared to monitoring serum P4 concentrations. Objective: To explore the correlation between mid-luteal serum 17-OH P4 levels and live birth rates and to explore the possible daytime variations in mid-luteal serum 17-OH P4. Design: Prospective cohort study. Patients: 614 women undergoing IVF-treatment and fresh embryo transfer. Intervention: All patients had serum 17-OH P4 measured 7 days after oocyte pick-up (OPU+7). Furthermore, on OPU+7, seven patients underwent repeated blood sampling during daytime to clarify the endogenous daytime secretory pattern of 17-OH P4. Outcome measure: Live birth rate. Secondary outcome measure: Daytime variation in serum 17-OH P4 levels. Results: The highest chance of a live birth was seen with mid-luteal 17-OH P4 between 6.0 and 14.0 nmol/l. The chance of a live birth was reduced below (RD -10%, p = 0.07), but also above the optimal range for 17-OH P4 (RD -12%, p = 0.04). Patients with diminished CL-function (17-OH P4 < 6 nmol/l) displayed clinically stable 17-OH P4 values, whereas patients with 17-OH P4 levels >6 nmol/l showed random 17-OH P4 fluctuations during daytime. Conclusion: The association between 17-OH P4 and reproductive outcomes is non-linear, and the negative effect of excessive CL-secretion seems to be just as strong as the negative effect of a reduced CL-function during the peri-implantation period.

SUBMITTER: Thomsen LH 

PROVIDER: S-EPMC6282693 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Mid-Luteal 17-OH Progesterone Levels in 614 Women Undergoing IVF-Treatment and Fresh Embryo Transfer-Daytime Variation and Impact on Live Birth Rates.

Thomsen Lise Haaber LH   Humaidan Peter P   Erb Karin K   Overgaard Martin M   Andersen Claus Yding CY   Kesmodel Ulrik Schiøler US  

Frontiers in endocrinology 20181129


<b>Introduction:</b> Corpus luteum (CL) produces progesterone (P<sub>4</sub>) and 17-OH progesterone (17-OH P<sub>4</sub>) during the luteal phase. Contrary to P<sub>4</sub>, 17-OH P<sub>4</sub> is not supplied as part of the luteal phase support following IVF-treatment. Therefore, measuring endogenous serum 17-OH P<sub>4</sub> levels may more accurately reflect the CL function compared to monitoring serum P<sub>4</sub> concentrations. <b>Objective:</b> To explore the correlation between mid-lut  ...[more]

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