Ontology highlight
ABSTRACT:
SUBMITTER: Davis JD
PROVIDER: S-EPMC6282936 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Davis John D JD Bansal Ashish A Hassman David D Akinlade Bolanle B Li Meng M Li Zhaoyang Z Swanson Brian B Hamilton Jennifer D JD DiCioccio A Thomas AT
Clinical pharmacology and therapeutics 20180402 6
This open-label drug-drug interaction study assessed whether blockade by dupilumab of interleukin (IL)-4 and IL-13 signaling affects the pharmacokinetics of drugs metabolized by cytochrome P450 (CYP450) enzymes. The pharmacokinetics of five CYP450 substrates given orally (midazolam, omeprazole, S-warfarin, caffeine, and metoprolol, metabolized by CYP3A, CYP2C19, CYP2C9, CYP1A2, and CYP2D6, respectively) were evaluated before and 28 days after initiation of dupilumab treatment (subcutaneous 300 m ...[more]