Dataset Information

NCR3 polymorphism, haematological parameters, and severe malaria in Senegalese patients.

ABSTRACT:

Background

Host factors, including host genetic variation, have been shown to influence the outcome of Plasmodium falciparum infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas NCR3-412 polymorphism (rs2736191) lying within this region was found to be associated with mild malaria.

Methods

Blood samples were taken from 188 Plasmodium falciparum malaria patients (76 mild malaria patients, 85 cerebral malaria patients, and 27 severe non-cerebral malaria patients). NCR3-412 (rs2736191) was analysed by sequencing, and haematological parameters were measured. Finally, their association with clinical phenotypes was assessed.

Results

We evidenced an association of thrombocytopenia with both cerebral malaria and severe non-cerebral malaria, and of an association of high leukocyte count with cerebral malaria. Additionally, we found no association of NCR3-412 with either cerebral malaria, severe non-cerebral malaria, or severe malaria after grouping cerebral malaria and severe non-cerebral malaria patients.

Conclusions

Our results suggest that NCR3 genetic variation has no effect, or only a small effect on the occurrence of severe malaria, although it has been strongly associated with mild malaria. We discuss the biological meaning of these results. Besides, we confirmed the association of thrombocytopenia and high leukocyte count with severe malaria phenotypes.

SUBMITTER: Thiam A

PROVIDER: S-EPMC6282937 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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<i>NCR3</i> polymorphism, haematological parameters, and severe malaria in Senegalese patients.

Thiam Alassane A Baaklini Sabrina S Mbengue Babacar B Nisar Samia S Diarra Maryam M Marquet Sandrine S Fall Mouhamadou Mansour MM Sanka Michel M Thiam Fatou F Diallo Rokhaya Ndiaye RN Torres Magali M Dieye Alioune A Rihet Pascal P

PeerJ 20181203

<h4>Background</h4>Host factors, including host genetic variation, have been shown to influence the outcome of <i>Plasmodium falciparum</i> infection. Genome-wide linkage studies have mapped mild malaria resistance genes on chromosome 6p21, whereas <i>NCR3-412</i> polymorphism (rs2736191) lying within this region was found to be associated with mild malaria.<h4>Methods</h4>Blood samples were taken from 188 <i>Plasmodium falciparum</i> malaria patients (76 mild malaria patients, 85 cerebral malar ...[more]

PMID: 30533319

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