Pathologic and molecular studies of enterovirus 71 infection in a fatal case from a recent epidemic in China: A case report.

ABSTRACT:

Rationale

Enterovirus 71 (EV71) is identified as the primary cause of hand, foot, and mouth disease (HFMD) and mainly infects the young infants. Though some fatal cases have been reported, the underlying mechanisms of EV71 infection remain elusive and more further pathologic and molecular studies of EV71 infection are needed.

Patient concerns

A 26-month-old girl with a history of fever and lethargy for 3 days and intermittent seizures for 2 hours associated with rash on 4 limbs was brought to a hospital.

Diagnoses

The autopsy was performed to identify the cause of death for a medical dispute. The results of histologic examination, immunohistochemistry (IHC), nested reverse transcription polymerase chain reaction (RT-PCR), and viral isolation confirmed that this patien

SUBMITTER: Xing J 

PROVIDER: S-EPMC6283094 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature