A literature mining-based approach for identification of cellular pathways associated with chemoresistance in cancer.

ABSTRACT: Chemoresistance is a major obstacle to the successful treatment of many human cancer types. Increasing evidence has revealed that chemoresistance involves many genes and multiple complex biological mechanisms including cancer stem cells, drug efflux mechanism, autophagy and epithelial-mesenchymal transition. Many studies have been conducted to investigate the possible molecular mechanisms of chemoresistance. However, understanding of the biological mechanisms in chemoresistance still remains limited. We surveyed the literature on chemoresistance-related genes and pathways of multiple cancer types. We then used a curated pathway database to investigate significant chemoresistance-related biological pathways. In addition, to investigate the importance of chemoresistance-related markers in pr

SUBMITTER: Oh JH 

PROVIDER: S-EPMC6283363 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature