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Case Report: Acute Transverse Myelitis after Zika Virus Infection.

ABSTRACT: We report here one case of Zika virus (ZIKV) infection associated with auto-immunity directed against the central nervous system in a Brazilian woman who developed acute transverse myelitis 9 days after recovery from an acute episode of fever with generalized erythema. Imaging of the spinal cord showed an elongated area on the T1-T10 level with gadolinium uptake. The diagnostic of the ZIKV infection was confirmed by cerebrospinal fluid and serum analysis. This patient had serum positivity for autoantibodies against myelin oligodendrocyte glycoprotein (MOG), a specific antibody against the myelin sheath. We propose that a direct central nervous system infection by ZIKV could lead to a specific auto-immunity against MOG protein.

SUBMITTER: Neri VC

PROVIDER: S-EPMC6283478 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Case Report: Acute Transverse Myelitis after Zika Virus Infection.

Neri Vanderson Carvalho VC Xavier Maria Filomena MF Barros Priscila Oliveira PO Melo Bento Cleonice C Marignier Romain R Papais Alvarenga Regina R

The American journal of tropical medicine and hygiene 20181201 6

We report here one case of Zika virus (ZIKV) infection associated with auto-immunity directed against the central nervous system in a Brazilian woman who developed acute transverse myelitis 9 days after recovery from an acute episode of fever with generalized erythema. Imaging of the spinal cord showed an elongated area on the T1-T10 level with gadolinium uptake. The diagnostic of the ZIKV infection was confirmed by cerebrospinal fluid and serum analysis. This patient had serum positivity for au ...[more]

PMID: 30277201

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