Association between metabolic parameters and glomerular hyperfiltration in a representative Korean population without chronic kidney disease.

ABSTRACT:

Aims

To investigate associations of glomerular hyperfiltration with other metabolic factors in a nationally representative dataset.

Methods

We analyzed cross-sectional data from 15,918 subjects with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m2 and urine albumin creation ratio (ACR) <30 mg/g, who participated in the 5th and 6th Korea National Health and Nutrition Examination Surveys. Hyperfiltration was defined as eGFR (CKD-EPI equation) exceeding the age- and sex-specific 95th percentile for healthy control subjects.

Results

Prevalence of hyperfiltration was 5.2% and that among normal, prediabetic, and diabetic subjects was 4.9%, 5.6%, and 7.3%, respectively, after adjusting for age, sex, and body weight (p for trend = 0.008). In a multiple logistic

SUBMITTER: Hong S 

PROVIDER: S-EPMC6283579 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature