Ontology highlight
ABSTRACT:
SUBMITTER: Harris N
PROVIDER: S-EPMC6283688 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Harris Nathan N Fetter Richard D RD Brasier Daniel J DJ Tong Amy A Davis Graeme W GW
Neuron 20181018 5
We define a homeostatic function for innate immune signaling within neurons. A genetic analysis of the innate immune signaling genes IMD, IKKβ, Tak1, and Relish demonstrates that each is essential for presynaptic homeostatic plasticity (PHP). Subsequent analyses define how the rapid induction of PHP (occurring in seconds) can be coordinated with the life-long maintenance of PHP, a time course that is conserved from invertebrates to mammals. We define a novel bifurcation of presynaptic innate imm ...[more]