Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC6284051 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Liu Yangguang Y Wu Meng M Wang Tianqi T Xie Yongli Y Cui Xiangling X He Liujun L He Yang Y Li Xiaoyu X Liu Mingliang M Hu Laixing L Cen Shan S Zhou Jinming J
Frontiers in pharmacology 20181130
Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current antiandrogen therapies induce resistant mutations at the hormone binding pocket (HBP) that convert the activity of these agents from antagonist to agonist. Thus, there is a high unmet medical need for the development of novel antiandrogens which circumvent mutation-based resistance. Herein, through the analysis of AR structures with ligands binding to the activation function-2 (AF2) ...[more]