Dataset Information

Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark - a historical comparison of productivity parameters in 20 nursery and 23 finishing herds.

ABSTRACT: Background:In practice, field evaluation of vaccine efficacy in individual herds is often based on a historical comparison of productivity data following initiation of vaccination. Being biased by time, this study design highly contrasts the more controlled, parallel-group design used for most initial vaccine efficacy studies but offers the possibility of including a larger number of animals and herds. As an important add-on to previous findings in controlled studies, the objective of this study was to evaluate the field efficacy of the ready-to-use combination vaccine Porcilis® PCV M Hyo (MSD Animal Health) by an observational historical study design using routinely generated herd productivity data. Results:Data on mortality, average daily weight gain and feed conversion rate were collected as yearly averages for one year prior to and one year after implementation of Porcilis® PCV M Hyo vaccination from 20 nursery and 23 finishing herds. When comparing pre- and post-vaccination periods, the average improvements in productivity data amounted to -?0.4 percentage points for mortality (p?=?0.014), +?5 g for average daily weight gain (p?=?0.555) and?-?0.06 feeding units(FU)/kg for feed conversion rate (p?=?0.074) in nursery herds and?-?0.5 percentage points for mortality (p?=?0.012), +?34 g for average daily weight gain (p

SUBMITTER: Nielsen GB

PROVIDER: S-EPMC6284288 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Field evaluation of a ready-to-use combined <i>Porcine circovirus</i> type 2 and <i>Mycoplasma hyopneumoniae</i> vaccine in Denmark - a historical comparison of productivity parameters in 20 nursery and 23 finishing herds.

Nielsen Gitte Blach GB Haugegaard John J Jolie Rika R

Porcine health management 20181207

<h4>Background</h4>In practice, field evaluation of vaccine efficacy in individual herds is often based on a historical comparison of productivity data following initiation of vaccination. Being biased by time, this study design highly contrasts the more controlled, parallel-group design used for most initial vaccine efficacy studies but offers the possibility of including a larger number of animals and herds. As an important add-on to previous findings in controlled studies, the objective of th ...[more]

PMID: 30546913

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Project description:BackgroundA discrete time, stochastic, compartmental model simulating the spread of Mycoplasma hyopneumoniae within a batch of industrially raised pigs was developed to understand infection dynamics and to assess the impact of a range of husbandry practices. A 'disease severity' index was calculated based on the ratio between the cumulative numbers of acutely and chronically diseased and infectious pigs per day in each age category, divided by the length of time that pigs spent in this age category. This is equal to the number of pigs per day, either acutely or chronically infectious and diseased, divided by the number of all pigs per all days in the model. The impact of risk and protective factors at batch level was examined by adjusting 'acclimatisation of gilts', 'length of suckling period', 'vaccination of suckling pigs against M. hyopneumoniae', 'contact between fattening pigs of different age during restocking of compartments' and 'co-infections in fattening pigs'.ResultsThe highest 'disease severity' was predicted, when gilts do not have contact with live animals during their acclimatisation, suckling period is 28 days, no vaccine is applied, fatteners have contact with pigs of other ages and are suffering from co-infections. Pigs in this scenario become diseased/infectious for 26.1 % of their lifetime. Logistic regression showed that vaccination of suckling pigs was influential for 'disease severity' in growers and finishers, but not in suckling and nursery pigs. Lack of contact between gilts and other live pigs during the acclimatisation significantly influenced the 'disease severity' in suckling pigs but had less impact in growing and finishing pigs. The length of the suckling period equally affected the severity of the disease in all age groups with the strongest association in nursery pigs. The contact between fatteners of different groups influenced the course of infection among finishers, but not among other pigs. Finally, presence of co-infections was relevant in growers and finishers, but not in younger pigs.ConclusionThe developed model allows comparison of different prevention programmes and strategies for controlling transmission of M. hyopneumoniae.

Dataset Information

Field evaluation of a ready-to-use combined Porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccine in Denmark - a historical comparison of productivity parameters in 20 nursery and 23 finishing herds.

Publications

Field evaluation of a ready-to-use combined <i>Porcine circovirus</i> type 2 and <i>Mycoplasma hyopneumoniae</i> vaccine in Denmark - a historical comparison of productivity parameters in 20 nursery and 23 finishing herds.

Similar Datasets

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