Genetic influence of Toll-like receptors on non-HIV cryptococcal meningitis: An observational cohort study.

ABSTRACT:

Background

Cryptococcal meningitis (CM) is a significant source of mortality, the pathogenesis of which has not been fully understood, especially in non-HIV infected populations. We aimed to explore the potential genetic influence of Toll-like receptor (TLR) on non-HIV CM.

Methods

This observational cohort study was done in two stages: a discovery stage and a validation stage. A case-control genetic association study was conducted between 159 non-HIV CM patients and 468 healthy controls. TLR SNPs significantly related to susceptibility went further validation in a second cohort of 583 subjects from a certain district. Associations among TLR SNPs, cerebrospinal fluid (CSF) cytokine concentrations, and clinical severity were explored in a third cohort of 99 previously untreate

SUBMITTER: Jiang YK 

PROVIDER: S-EPMC6284510 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature