Strategies for optical control and simultaneous electrical readout of extended cortical circuits.

ABSTRACT:

Background

To dissect the intricate workings of neural circuits, it is essential to gain precise control over subsets of neurons while retaining the ability to monitor larger-scale circuit dynamics. This requires the ability to both evoke and record neural activity simultaneously with high spatial and temporal resolution.

New method

In this paper we present approaches that address this need by combining micro-electrocorticography (μECoG) with optogenetics in ways that avoid photovoltaic artifacts.

Results

We demonstrate that variations of this approach are broadly applicable across three commonly studied mammalian species - mouse, rat, and macaque monkey - and that the recorded μECoG signal shows complex spectral and spatio-temporal patterns in response to optical sti

SUBMITTER: Ledochowitsch P 

PROVIDER: S-EPMC6284522 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature