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Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.


ABSTRACT: BACKGROUND:Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract. OBJECTIVE:We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. DESIGN:We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression. RESULTS:HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-?g/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend ? 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63). CONCLUSION:These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.

SUBMITTER: Hughes DJ 

PROVIDER: S-EPMC6284791 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

Hughes David J DJ   Duarte-Salles Talita T   Hybsier Sandra S   Trichopoulou Antonia A   Stepien Magdalena M   Aleksandrova Krasimira K   Overvad Kim K   Tjønneland Anne A   Olsen Anja A   Affret Aurélie A   Fagherazzi Guy G   Boutron-Ruault Marie-Christine MC   Katzke Verena V   Kaaks Rudolf R   Boeing Heiner H   Bamia Christina C   Lagiou Pagona P   Peppa Eleni E   Palli Domenico D   Krogh Vittorio V   Panico Salvatore S   Tumino Rosario R   Sacerdote Carlotta C   Bueno-de-Mesquita Hendrik Bastiaan HB   Peeters Petra H PH   Engeset Dagrun D   Weiderpass Elisabete E   Lasheras Cristina C   Agudo Antonio A   Sánchez Maria-José MJ   Navarro Carmen C   Ardanaz Eva E   Dorronsoro Miren M   Hemmingsson Oskar O   Wareham Nicholas J NJ   Khaw Kay-Tee KT   Bradbury Kathryn E KE   Cross Amanda J AJ   Gunter Marc M   Riboli Elio E   Romieu Isabelle I   Schomburg Lutz L   Jenab Mazda M  

The American journal of clinical nutrition 20160629 2


<h4>Background</h4>Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract.<h4>Objective</h4>We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.<h4>Design</h4>We assessed prediagnostic selenium status by measuring serum concentrations of selenium and se  ...[more]

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