Ontology highlight
ABSTRACT:
SUBMITTER: Simonneau M
PROVIDER: S-EPMC6284862 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Simonneau Marie M Frouin Eric E Huguier Vincent V Jermidi Cynthia C Jégou Jean François JF Godet Julie J Barra Anne A Paris Isabelle I Levillain Pierre P Cordier-Dirikoc Sevda S Pedretti Nathalie N Bernard François Xavier FX Lecron Jean Claude JC Morel Franck F Favot Laure L
Oncotarget 20181123 92
Cutaneous squamous cell carcinoma (cSCC) is the second most common keratinocyte malignancy and accounts for 20% of skin cancer deaths. Cancer is closely related to inflammation, but the contribution of the tumor microenvironment to cSCC development is poorly understood. We previously showed that oncostatin M (OSM), a cytokine belonging to the IL-6 family, promotes normal keratinocyte proliferation and migration, skin inflammation, and epidermal hyperplasia, both <i>in vitro</i> and <i>in vivo</i ...[more]