Ontology highlight
ABSTRACT:
SUBMITTER: Davar D
PROVIDER: S-EPMC6286160 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Davar Diwakar D Wang Hong H Chauvin Joe-Marc JM Pagliano Ornella O Fourcade Julien J JJ Ka Mignane M Menna Carmine C Rose Amy A Sander Cindy C Borhani Amir A AA Karunamurthy Arivarasan A Tarhini Ahmad A AA Tawbi Hussein A HA Zhao Qing Q Moreno Blanca H BH Ebbinghaus Scott S Ibrahim Nageatte N Kirkwood John M JM Zarour Hassane M HM
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20181025
<h4>Purpose</h4>Objective responses are reported in 34% to 37% of patients with programmed death-1 (PD-1)-naïve advanced melanoma treated with PD-1 inhibitors. Pre-existing CD8+ T-cell infiltrate and interferon (IFN) gene signature correlate with response to PD-1 blockade. Here, we report a phase Ib/II study of pembrolizumab/pegylated (PEG)-IFN combination in PD-1-naïve advanced melanoma.<h4>Patients and methods</h4>PEG-IFN (1, 2, and 3 μg/kg per week) was dose escalated using a modified toxicit ...[more]