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A phenotype of increased sleepiness in a mouse model of pulmonary hypertension and right ventricular hypertrophy.


ABSTRACT: The relationship between cardiovascular disease and abnormalities in sleep architecture is complex and bi-directional. Sleep disordered breathing (SDB) often confounds human studies examining sleep in the setting of heart failure, and the independent impact of isolated right or left heart failure on sleep is difficult to assess. We utilized an animal model of right heart failure using pulmonary artery banding (PAB) in mice to examine the causal effect of right heart failure on sleep architecture. Four weeks after PAB or sham (control) surgery, sleep was measured by polysomnography for 48 hours and right ventricular (RV) hypertrophy confirmed prior to sacrifice. PAB resulted in right ventricular hypertrophy based on a 30% increase in the Fulton Index (p < 0.01). After PAB, mice spent significantly more time in NREM sleep compared to the control group over a 24 hour period (53.5 ± 1.5% vs. 46.6 ± 1.4%; p < 0.01) and exhibited an inability to both cycle into REM sleep and decrease delta density across the light/sleep period. Our results support a phenotype of impaired sleep cycling and increased 'sleepiness' in a mouse model of RV dysfunction.

SUBMITTER: Davis EM 

PROVIDER: S-EPMC6286175 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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A phenotype of increased sleepiness in a mouse model of pulmonary hypertension and right ventricular hypertrophy.

Davis Eric M EM   Baust Jeffrey J JJ   O'Donnell Brett J BJ   Shah Faraaz A FA   McDowell Angela A   Guo Lanping L   O'Donnell Christopher P CP  

PloS one 20181207 12


The relationship between cardiovascular disease and abnormalities in sleep architecture is complex and bi-directional. Sleep disordered breathing (SDB) often confounds human studies examining sleep in the setting of heart failure, and the independent impact of isolated right or left heart failure on sleep is difficult to assess. We utilized an animal model of right heart failure using pulmonary artery banding (PAB) in mice to examine the causal effect of right heart failure on sleep architecture  ...[more]

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