IL-6: a cytokine at the crossroads of autoimmunity.
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ABSTRACT:
SUBMITTER: Jones BE
PROVIDER: S-EPMC6286200 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
IL-6: a cytokine at the crossroads of autoimmunity.
Jones Britta E BE Maerz Megan D MD Buckner Jane H JH
Current opinion in immunology 20180921
IL-6 is implicated in the development and progression of autoimmune diseases in part by influencing CD4 T cell lineage and regulation. Elevated IL-6 levels drive inflammation in a wide range of autoimmune diseases, some of which are also characterized by enhanced T cell responses to IL-6. Notably, the impact of IL-6 on inflammation is contextual in nature and dependent on the cell type, cytokine milieu and tissue. Targeting the IL-6/IL-6R axis in humans has been shown to successfully ameliorate ...[more]
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