T cell-derived lymphotoxin limits Th1 response during HSV-1 infection.
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ABSTRACT:
SUBMITTER: Yang K
PROVIDER: S-EPMC6286317 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
T cell-derived lymphotoxin limits Th1 response during HSV-1 infection.
Yang Kaiting K Liang Yong Y Sun Zhichen Z Liu Longchao L Liao Jing J Liao Jing J Xu Hairong H Zhu Mingzhao M Fu Yang-Xin YX Fu Yang-Xin YX Peng Hua H
Scientific reports 20181207 1
Though lymphotoxin (LT) is highly expressed by type I helper T (Th1) cells, its contribution to CD4<sup>+</sup> T cell differentiation during infections and diseases remains a mystery. In HSV-1 infection, we observed that LTβR signaling is required to limit the Th1 response. Using bone marrow chimeric mice, mixed-T-cell chimeric mice, and LTβR in vivo blockades, we unexpectedly observed that LT, especially T cell-derived LT, played an indispensable role in limiting the Th1 response. The LTβR-Ig ...[more]
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