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T cell-derived lymphotoxin limits Th1 response during HSV-1 infection.


ABSTRACT: Though lymphotoxin (LT) is highly expressed by type I helper T (Th1) cells, its contribution to CD4+ T cell differentiation during infections and diseases remains a mystery. In HSV-1 infection, we observed that LT?R signaling is required to limit the Th1 response. Using bone marrow chimeric mice, mixed-T-cell chimeric mice, and LT?R in vivo blockades, we unexpectedly observed that LT, especially T cell-derived LT, played an indispensable role in limiting the Th1 response. The LT?R-Ig blockade promoted the Th1 response by increasing infiltration of monocytes and monocyte-derived DCs and up-regulating IL-12 secretion in the lymphoid environment. Our findings identified a novel role for T cell-derived LT in manipulating Th1 differentiation.

SUBMITTER: Yang K 

PROVIDER: S-EPMC6286317 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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T cell-derived lymphotoxin limits Th1 response during HSV-1 infection.

Yang Kaiting K   Liang Yong Y   Sun Zhichen Z   Liu Longchao L   Liao Jing J   Liao Jing J   Xu Hairong H   Zhu Mingzhao M   Fu Yang-Xin YX   Fu Yang-Xin YX   Peng Hua H  

Scientific reports 20181207 1


Though lymphotoxin (LT) is highly expressed by type I helper T (Th1) cells, its contribution to CD4<sup>+</sup> T cell differentiation during infections and diseases remains a mystery. In HSV-1 infection, we observed that LTβR signaling is required to limit the Th1 response. Using bone marrow chimeric mice, mixed-T-cell chimeric mice, and LTβR in vivo blockades, we unexpectedly observed that LT, especially T cell-derived LT, played an indispensable role in limiting the Th1 response. The LTβR-Ig  ...[more]

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