Ontology highlight
ABSTRACT:
SUBMITTER: Bisignano P
PROVIDER: S-EPMC6286348 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Bisignano Paola P Ghezzi Chiara C Jo Hyunil H Polizzi Nicholas F NF Althoff Thorsten T Kalyanaraman Chakrapani C Friemann Rosmarie R Jacobson Matthew P MP Wright Ernest M EM Grabe Michael M
Nature communications 20181207 1
Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes. Current therapeutics are phlorizin derivatives that contain a sugar moiety bound to an aromatic aglycon tail. Here, we develop structural models of human SGLT1/2 in complex with inhibitors by combining computational and functional studies. Inhibitors bind with the sugar moiety ...[more]